You can get these wholesale from China from "reputable" gray-market wholesalers who get the chemicals made at contract manufacturing facilities. BYO QA/QC though, as with all non-FDA drugs. That's the huge catch, and it sucks for consumers. Testing just for active ingredient is >$100 and takes about a month. Testing for proper buffering agents, harmful contaminants, microbial contamination, etc is essentially unavailable at all.
Semaglutide is very, very cheap in the gray market. It's somewhat less effective than Tirzepatide and has slightly more side effects if you ramp up the dosage too quickly.
If an annual amount is purchased on the gray market, this brings the monthly cost down to:
- Semaglutide: $10/month
- Tirzepatide: $60/month
- Liraglutide: $87/month
- LY3437943: I have not yet seen this available, but it looks like distributors are notifying manufacturers of latent demand and are working to build up a supply chain.
Note that in the USA, it is legal to import certain amounts of FDA-approved drugs if you have a prescription for them. However, just because something is the exact same chemical as an FDA-approved drug does not make it an FDA-approved drug. It must be manufactured in an FDA certified facility and be the same brand/manufacturer/packaging/labeling/etc as the approved drug.
e.g. importing generic Sildenafil/Viagra is legal if you can find the Teva(tm) brand generic sildenafil in, say, Mexico or Canada for a better price. But it must be the pills manufactured by Teva in the appropriate facility with NDC #0093-5342-56[0].
If you import generic sildenafil "Cenforce" from the (very legitimate but not FDA-approved) Indian pharmaceutical manufacturer "Centurion Laboratories"...
...that would still be potentially criminal smuggling. Even if the pills you import show via laboratory test that they precisely match your medical prescription, they are not "FDA approved" and therefore not legal to import.
They actually have to test to that degree to follow aviation standards (DO-178b [0]) because they're used in aviation equipment.
Dr. Hipp said he started really following it when Android came out and included SQLite and suddenly there were 200M mobile SQLite users finding edge cases: https://youtu.be/Jib2AmRb_rk?t=3413
Lightly edited transcript here:
> It made a huge difference. That that was when Android was just kicking off. In fact Android might not have been publicly announced, but we had been called in to help with getting Android going with SQLite. [Actually], they had been publicly announced and there were a bunch of Android phones out and we were getting flooded with problems coming in from Android.
> I mean it worked great in the lab it worked great in all the testing and then [...] you give it to 200 million people and let them start clicking on their phone all day and suddenly bugs come up. And this is a big problem for us.
> So I started doing following this DO-178b process and it took a good solid year to get us there. Good solid year of 12 hour days, six days a week, I mean we really really pushed but we got it there. And you know, once we got SQLite to the point where it was at that DO-178b level, standard, we still get bugs but you know they're very manageable. They're infrequent and they don't affect nearly as many people.
> So it's been a huge huge thing. If you're writing an application deal ones, you know a website, a DO-178b/a is way overkill, okay? It's just because it's very expensive and very time-consuming, but if you're running an infrastructure thing like SQL, it's the only way to do it.
A TDCS device. Trans-cranial Direct Current Stimulation, mostly experimental, somewhat proven for short-term depression and cognition improvement. Motivation was my solution would be simpler and easier to control as well as include triple safety.
I had little trust for the Chinese IC steered devices nor the early US attempters at pop market that refuse to describe even their safety approach.
Pleased with my personal results. Would not openly recommend doing it, because the DIY route as well as adopting TDCS do require that you can competently read medical studies. At least half of those I browsed fail good science test even at first glance.
And then of course the manufacturers and sellers are even worse, such as they are quite good at parroting misquotes of study results for marketing and PR.
Next plan is build an ECG and my own medical ultrasound, although with that one it is probably best to wait for about 5 to 7 years till the new-tech ultrasound generators get to market.
The full cap table probably not. But you generally don't need that to ascertain the most important parts of startup compensation.
I generally ask these questions:
1. What was the pre/post money valuation of the company at the last round.
2. How much runway do they have right now including already planned increases in burn (i.e hiring plans for the quarter/year).
3. What % interest in the company would my options grant represent? (you use this in combination with the information about the valuation to determine value of said grant)
4. Who are the major non-founder investors in the company? (this is generally public knowledge because investors love to announce these but it's worth asking). Sometimes the CEO will also divulge details about how they work with their investors, level of involvement, board seats etc. CEOs love to talk about these things for some reason.
5. When do they plan to raise money next and do they feel like they are meeting the metrics required for an up round? If not then how does my hiring or other planned hiring seek to address that?
The last question is actually really important and generally how I a) tie my employment to actual value at the company and b) justify my compensation in negotiation stage and/or later negotiations when I can show how my performance has directly affected these important metrics.
Any company worth their salt at the sort of stage where these questions are relevant will answer these, the degree of detail will depend on transparency of the leadership.
Generally speaking when looking to join a company of this size you will be meeting with the CEO, usually after meeting everyone else and before negotiating compensation - that is when you ask these questions and this is exactly what that meeting is for.
If they don't want to answer these then take that as a sign things are worse than they seem and perhaps negotiate for a more cash rich compensation and don't bet hard on the companies future.
You have to go through the usual install process for macOS, and can then install your applications. Whether this is legal or ethical is a subject for your own research.
Semaglutide is very, very cheap in the gray market. It's somewhat less effective than Tirzepatide and has slightly more side effects if you ramp up the dosage too quickly.
If an annual amount is purchased on the gray market, this brings the monthly cost down to:
- Semaglutide: $10/month
- Tirzepatide: $60/month
- Liraglutide: $87/month
- LY3437943: I have not yet seen this available, but it looks like distributors are notifying manufacturers of latent demand and are working to build up a supply chain.
Note that in the USA, it is legal to import certain amounts of FDA-approved drugs if you have a prescription for them. However, just because something is the exact same chemical as an FDA-approved drug does not make it an FDA-approved drug. It must be manufactured in an FDA certified facility and be the same brand/manufacturer/packaging/labeling/etc as the approved drug.
e.g. importing generic Sildenafil/Viagra is legal if you can find the Teva(tm) brand generic sildenafil in, say, Mexico or Canada for a better price. But it must be the pills manufactured by Teva in the appropriate facility with NDC #0093-5342-56[0].
If you import generic sildenafil "Cenforce" from the (very legitimate but not FDA-approved) Indian pharmaceutical manufacturer "Centurion Laboratories"...
...that would still be potentially criminal smuggling. Even if the pills you import show via laboratory test that they precisely match your medical prescription, they are not "FDA approved" and therefore not legal to import.
A lot of people do though!
0: https://ndclist.com/ndc/0093-5342/package/0093-5342-56