I doubt it'll help since the bill makes it problematic to facilitate any illegal behavior. So E2EE won't help, they'll just slap you for facilitating stuff.
If someone finds out someone did do something illegal with it (obtaining plaintext through various means or someone is being convicted by other means) then you're definitely in for it.
Then every single P2P host will have to take it down, which might take a long while with how slow DMCA/whatever takes.
Myself, personally, I'd comply with legal takedowns because I don't want to get thrown in prison. But that doesn't mean it won't be exceptionally hard for things to be removed from a cryptographically secure P2P network.
