I’ll take the chance to link to Derek Yu’s (of Spelunky fame) pixel art tutorial, where he explains techniques such as anti-aliasing and sel-out: https://www.derekyu.com/makegames/pixelart.html
Since the cutoff for duplicates is about a year (https://news.ycombinator.com/newsfaq.html) and the most recent major thread was only a few weeks ago, I've marked the current post as a dupe. (Sorry ellieh!)
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