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But increases diarrhea on a scale thought unfathomable? Every time you meet one of those 'life extension' types taking Metformin just know that they aren't living their best life in the bathroom.


The GI side effects of metformin are usually short lived. They tend to last about a week or so after starting the drug or increasing the dose. Some people do have longer lasting side effects, but metformin is one of the best tolerated drugs we have.


I took metformin for about two weeks after being incorrectly diagnosed with T2 diabetes (I actually have T1, but some doctors seem to think it's impossible for adults to be diagnosed with it) and stomach / digestion / diarrhea issues only lasted about 2 days for me.


I take Metformin every day and have not had any side effects (including diarrhea).


What's your reason for taking it? The purported longevity benefits?


Yes, I take it for the possible longevity benefits.


Same here


I stopped a while back when I read that it reduces testosterone level significantly: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5296448/#:~:tex....

Do you notice anything to support this?


nope - no side effects at all that I can tell


Would you rather have tumours?


How does speculation drive the price of lumber up?


Speculators are buying lumber futures. When too many start betting that the price will go up it becomes a self fulfilling prophecy.


Many Twitter users with a high follower count have turned off replies from people they don’t follow. So it’s basically just an announcement platform for perceived genius.


Looks like a massive attack. I wonder if the goal of the attacker is to short the stock.


Short interest on WDC isn't absurdly high, so, if that's the motivation, it's a pretty risky move to make not a lot of money.

https://www.nasdaq.com/market-activity/stocks/wdc/short-inte...


You don't need short interest to make money shorting the stock. Short interest is useful for trying to squeeze people shorting the stock.

To make money off shorting the stock, all you need is for the stock to drop in price


I think his point is that the short interest is low, therefore it's not that heavily shorted, so if the attacker was doing the hack and shorting the stock to make money on the dip, he wasn't shorting enough to make that much money. Either that, or the attacker didn't short the stock in the first place.


That would be a silly point. Puts don't even show up in the short interest and are a great way to short a stock.


They do, indirectly because market makers hedge the puts they sell by shorting the underlying.

https://www.investopedia.com/terms/d/deltagamma-hedging.asp


Not every put seller gamma hedges. And the extent to which they do depends on how ITM the option is.


Your comment contradicts your previous comment.

> There's no indication WIV was doing any gain of function research.


No it doesn't.


https://mobile.twitter.com/R_H_Ebright/status/14052391280532...

> The work met--unequivocally--the definition of gain-of-function research of concern under the 2014 Pause.


How quiet is that? My problem with air conditioners is noise. I end up wearing earplugs.

Are they not selling it anymore?


Why? They are worried about American scientists chasing after them?


It is a political thing. Japan has DDBJ (https://www.ddbj.nig.ac.jp/index-e.html). EU has ENA/EBI (https://www.ebi.ac.uk/ena/browser/home). Maybe China wants to have its own.

More Chinese institutes are encouraging their scientists to deposit human bio-sample data to their own servers. Some grants even require them to do so.


This is not true.

https://twitter.com/r_h_ebright/status/1405239078698815489?s...

> The Wuhan lab constructed novel chimeric viruses that combined spike genes from new bat SARS-related coronaviruses with the genomic backbone of another bat SARS-related coronavirus.

> These were viruses that were novel, not viruses that were present in nature.

https://journals.plos.org/plospathogens/article?id=10.1371/j...


A rando on twitter is not a source, they're just citing the same circular reasons speculation as assertive truth and there's no proof.

And your citation is to:

> Discovery of a rich gene pool of bat SARS-related coronaviruses provides new insights into the origin of SARS coronavirus

Yes. There is a massive amount that we still don't know about the genoomic diversity of sarbecoviruses in bats in and around China. This is the kind of study that we need a whole lot more of. No idea what your point is.


1) It's Richard Ebright who has been quoted in numerous articles. He isn't some "rando on twitter." You didn't read his sub-tweets.

2) You only read the title of the article I linked that was in sub-tweets. See the following tweet:

https://mobile.twitter.com/R_H_Ebright/status/14052391926286...

> The construction of novel chimeric SARS-related coronaviruses able to infect human cells and lab animals at WIV (1) was published with acknowledgment to NIH grant AI110964 (https://journals.plos.org/plospathogens/article?id=10.1371/j...) and (2) was reported to NIH under NIH grant AI110964 (https://reporter.nih.gov/search/0dVX_GElSEGDOsNMZq7qaQ/proje...)

So, yes, gain of function research was happening at WIV.


There's not gain of function. The WIV1 virus already binds to hACE2, putting another spike on it and finding that spike also binds to hACE2 in vitro doesn't enhance its function at all. It does tell you how much that spike binds to hACE2.

You can debate if that's a good idea or not, but SARS-CoV-2 is way too distant from WIV1/SARS-CoV-1 to arise from any lab experiment with chimeric viruses. And its also too far away from RaTG13, which still needs decades of evolution to turn into SARS-CoV-2.


https://mobile.twitter.com/R_H_Ebright/status/14052391280532...

> The work met--unequivocally--the definition of gain-of-function research of concern under the 2014 Pause.

> The work met--unequivocally--the definition of potential pandemic pathogen enhancement under the 2017 HHS Potential Pandemic Pathogen Control and Oversight (P3CO) Framework.


It’s scientists that fund or support gain of function research at WIV. So anyone involved with Ecohealth is fair game.

I don’t see anything political here. If Fauci and Daszak had come out against dangerous experiments at low biosafety levels we wouldn’t be talking about them.


I don’t think Richard Ebright is demanding an investigation for political reasons. He refers to Trump as a sociopath.


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