Hacker Newsnew | past | comments | ask | show | jobs | submit | rscho's commentslogin

~1/10.000 patient-years is a non-concern ?! I hope you're not an epidemiologist.


I think this depends on the context. For your epidemiologist perspective, or looking at populations, that's a big rate! (Given how much metformin is taken) Would be easy to find people who suffer from it.

From the perspective of "Should I be worried about side effects from taking this drug / should I not take this because it might give me this effect", I think this falls under "be aware of symptoms and stop or weigh the costs if you get it, but you're probably fine".


Metabolic acidosis. Not trivial at all.


Which happily, is totally devoid of side effects.


Amusingly, this was a very common if not the most common stance on this very website some time ago. Surely, don't look for assistance on the internet regarding memory issues.


Don't come and spoil our nice individualism with populational effects, you filthy rationalist !


Of course deskilling will happen. But marketing says the machine is more often right than the operator is, and people also want it (we can replace docs with AI today, yadda yadda). Soooo... to be expected? It's just that the machine has to work correctly, which is not on the endoscopist, right?


How to hedge a bet 101:

1.you bet on risky stuff using something of value (money, health,...)

2.since you're unsure whether your bet will pay off, you bet some more on some other risky stuff, just to be sure.

BTW if you were wondering, of course all those proposed weird life-prolonging treatments are totally devoid of side-effects.


Never put 100% of your savings into a single slot machine. Take 10% of your savings to 10 different casinos and distribute them to 10 slot machines in each, in order to hedge.


Oh there's plenty of people selling "side effect free" life extension supplements. But there's another name for side effect free medication: effect free.


You've got horrible taste in cocktails.


Vodka Red Bull is not a cocktail it is a drug.


You're absolutely right! This man's got horrible taste in drugs.


Surprisingly, many people seem to think that pushing a few random pills into a machine optimized over some million years of evolution will tune it so it works better. Go figure...


It works for the majority of modern medicine, so it's not all that black and white.


Yes, although even for modern medicine curative and preventative strategies are very distinct. Sure, they'll give you pills to compensate for a problem you already have. But there are few meds that protect you against stuff you'll maybe catch in the future. Vaccines and antibiotics are obvious examples, but I'm not aware of many others. The rest of preventative strategies overwhelmingly consists in correcting deficits or excesses (calories, vitamins, sleep, exercise etc.)


Lack of pharmacology background doesn't seem like the biggest issue when extrapolating from mouse to human.


Consider applying for YC's Winter 2026 batch! Applications are open till Nov 10

Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: