Its mathematically derived. A0 is exactly 1m2 in area. The side lengths are at a ratio of sqrt(2), that means you can cut any A paper size in half and get the size below it. B series are the same ratio, but B0 has a width of 1m instead.
I'm not an expert in pharmaceutical chemistry, but this looks like a series of relatively complex and low yield reactions. Would it be likely that this would push the price of this product beyond what is reasonable for a general use drug?
The starting point is ~free (like 2 or 4 cents retail per dose for generic in the US). Given my relatively light usage of pain drugs, I would certainly pay 10x that for reduced toxicity.
And then it isn't necessarily the case that the identified reactions are the most cost effective available.
If you have light usage, do you need reduced toxicity?
Acetaminophen's effective dose is pretty close to the dangerous dose, but I would take light use to mean you take something maybe once a month max and only a single dose (or maybe even just one pill when the dose is two pills). At that level of use, I don't think you're at risk of anything.
Otoh, if the title is accurate and it can be more effective at pain release and less damaging to the liver, that would be great for people who experience pain frequently.
For purposes like graphic design or color grading it's usually more useful to first focus on lightness contrast, then pick hue and chroma afterward. Having uniform steps of ΔE is not really important, and using that as a primary criterion will usually make for worse choices. Color is multidimensional and trying to simplify it to a single distance function is substantially misleading for this context.
The main purpose of ΔE is specifying error tolerances for specified colors / measuring small differences between nearby colors, so that e.g. if you hire someone to paint a car or print a magazine you can check that their output matches expectation sufficiently. For colors that are significantly different ΔE isn't that helpful a practical tool.
> Our eyes are much more sensitive to Blue/Violet, and less sensitive to green.
Hm? It's the exact opposite. That's why the full-intensity RGB green looks much brighter than the full-intensity blue. To convert RGB to pure luminance (gray), you do something like 0.3 * R + 0.6 * G + 0.1 * B, meaning green contributes six times as much as blue.
A bit outdated now, but Saturn TAS made a very good TAS. It optimized door transitions to get the best in-game time. Unfortunately this was right as the rules changed between tracking in-game time and real-time, so the run never made it into the leaderboard. It made him stop making TASes for Super Metroid altogether.
https://www.youtube.com/watch?v=y3THRhCgCO4
> I'm confused as to whether it applies to online gaming
As written, it should. Which is ridiculous, and it's a ridiculous law in the first place. I'm loathe to discuss politics, but by god both Labor and the LNP are woeful when it comes to tech policy.
Im still dirty about the NBN. Every now and then i go back home to visit and are rudely reminded that the network speeds suck. What do you mean i have to in wait for things to download? What do you mean I'm the the biggest city in the country and are on a copper line getting 5 Mbps....
Where i live, 80% of all vehicles are passenger vehicles. I'm not sure that the extra wheels on semis would make up for that difference, especially with the slow increase in size of passenger vehicles.
Hard long lasting compounds don’t actually make up for fully loaded semi’s weight. They are much larger tires and with consistent heavy loads may only last 25k miles (or 100k with light loads).
So more and much larger tires and fairly similar lifespan = they liked make up a significant majority of tire pollution.
I used to follow the development blogs of the witness. I remember reading somewhere that accessibility was why you can beat the game with only 7/10 sections complete. You can completely skip both the colour puzzles and sound puzzles and still finish the game. Its an interesting compromise.
As someone who is colorblind, you are correct. Those puzzles are just about impossible for me.
- Undercoat color
- Number of coats
- Gloss Level
- Size of colored area
- Surrounding Colour
- Combination of tinters used by each brand. (Different tinters can make colours metameric)
- Light Source (Incandescent, D65, LED, Fluorescent)
- Monitor Color Space (sRGB, DCI-P3)
- Color Space / Model used for conversion (Lab, Luv, Lch)
- Colour Difference dE Model Used (CIE76, CMC, CIE00)
- Precision and spectral range of the spectrophotometer used.
Etc