I'm starting a self-publish project, and am looking at using Pollen[1] along with some CSS based on Edward Tufte's ideas[2].

I'm not a designer by any means, but I'm having fun with this, and the result is looking pretty reasonable so far. (And learning one programming language while writing a book on another is kind of cool)

[1] http://docs.racket-lang.org/pollen/ [2] https://edwardtufte.github.io/tufte-css/