You can play Factorio with the enemies turned off. I do that too, because I find getting distracted by enemies annoying. The downside is that the whole military part of the research tree becomes pointless.

Another way is to have enemies but set them to be peaceful until you attack them first. Downside is that it's finicky. The enemies love to roam randomly, so if you accidentally hit one with a car or build a rail track too close to one of their bases such that one of them wanders on to it and gets run over, all the enemies on the map will instantly become hostile.