Thanks for the link. I looked around and I saw that 2 uM Zinc inhibited SARS-CoV-1 in vitro, while human cellular concentrations of zinc are typically in the tens to hundreds mM range.
As a non-expert, there are two things that occur to me. That either something weird is going on, or zinc is very tightly controlled by the body and the range is really important. This means that taking extra dietary zinc without an ionophore probably wouldn't do much. So maybe CQ would help promote additional Zinc. According to one review article I was reading, Zinc concentration is naturally increased during immune response unless the virus hijacks the Zinc system.
This information makes me open to the possibility CQ is doing something, but so far the real world results have been unclear. One study showed that CQ had no effect on patients in France. If it's the Zinc that's making the difference and they didn't give Zinc, that would possibly explain the results, but the body also has abundant supplies of Zinc and adjusting intracellular concentration by 2/1000 of the ambient concentration shouldn't be a big deal.
As a non-expert, there are two things that occur to me. That either something weird is going on, or zinc is very tightly controlled by the body and the range is really important. This means that taking extra dietary zinc without an ionophore probably wouldn't do much. So maybe CQ would help promote additional Zinc. According to one review article I was reading, Zinc concentration is naturally increased during immune response unless the virus hijacks the Zinc system.
This information makes me open to the possibility CQ is doing something, but so far the real world results have been unclear. One study showed that CQ had no effect on patients in France. If it's the Zinc that's making the difference and they didn't give Zinc, that would possibly explain the results, but the body also has abundant supplies of Zinc and adjusting intracellular concentration by 2/1000 of the ambient concentration shouldn't be a big deal.