That looks like a 12-week keto diet, applied to 21 patients who already have AD. The measured results were cognitive scores on testing, which improved.
Consequently, it suggests someone who is already impaired due to AD may be able to improve symptoms from a keto diet (vs a low-fat one).
But the general consensus is that reversing or alleviating AD symptoms is a different task than preventing it in the first place.
The linked article here is talking more about the latter, and specifically for preventing non-hereditary AD.
I agree. I'm not talking about a one-off study showing a minor improvement though (which would be likely to not replicate, etc.), I'm referring to a much stronger effect which in principle is addressing the origin of the disease.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6720297/ - a review of various studies, concludes that "Keto diet may modulate a broad array of metabolic and signaling changes underlying the pathophysiology of neurodegenerative disorders. Based on the limited animal studies and clinical trials, keto diet has beneficial effects for enhancing mitochondrial function and cellular metabolism. It is associated with improved cognitive performance in elderly adults with Alzheimer's disease. The improvement of the cognitive outcomes depends on the level and duration of ketosis."
https://academic.oup.com/advances/article/11/6/1583/5864685?... - another review, concludes that "The results underline that, collectively, the efficacy of ketogenic therapy in MCI/AD appears promising, indicating that it is more than a symptomatic remedy (137). Nevertheless, research is still scattered and heterogeneous in terms of study design, intervention, participants, and outcomes of interest."
https://pubmed.ncbi.nlm.nih.gov/15123336/ - study on MCT oil which raises levels of ketones, abstract says "Higher ketone values were associated with greater improvement in paragraph recall with MCT treatment relative to placebo across all subjects (P=0.02). Additional research is warranted to determine the therapeutic benefits of MCTs for patients with AD and how APOE-4 status may mediate beta-OHB efficacy."
Additionally Alzheimer's is actually referred to by a large number of folks in the field as "type 3 diabetes" & as far as I understand there is a large amount of overlap between the two diseases; we have studies showing that diabetes can be nearly or totally cured by carbohydrate restriction:
https://pubmed.ncbi.nlm.nih.gov/29417495/ - of 349 participants, 94% were able to eliminate or reduce insulin therapy after 1 year (57% discontinued their prescriptions entirely).
The book "The Alzheimer's Antidote" by Amy Berger is a great resource if you are open minded enough to be willing to look at informational resources once step above scientific controlled studies (unfortunately many folks are not).
> willing to look at informational resources once step above scientific controlled studies (unfortunately many folks are not).
The End of Alzheimer's by Dr Dale Bredesen is all about "scientific controlled studies" and comes to the same conclusion about keto diets. No need to be open-minded :)
All the books I read cite plenty of studies, including the one I mentioned, which is why I call it "one step above scientific studies", but you get called a whacko nonetheless if you or the author hold any opinions even moderately outside of the mainstream dialogue / mainstream medicine.
My original comment on this thread is at -1 even though what I said was factually correct (and I found all my linked sources above via exactly what I said, a quick Google search). Another of my comments on this post has the classic reply "ah but the author of your study has been accused of quackery if I google his name".
So I'd say a bit more open-mindedness would be in order.
Yes, I am sorry you are getting such responses. The bottom line is there are multiple causes and types of Alzheimer's. So there are also multiple preventative measures. I'm no expert but, like you, have studied and read a lot, and that's my take.
Consequently, it suggests someone who is already impaired due to AD may be able to improve symptoms from a keto diet (vs a low-fat one).
But the general consensus is that reversing or alleviating AD symptoms is a different task than preventing it in the first place.
The linked article here is talking more about the latter, and specifically for preventing non-hereditary AD.