Hacker Newsnew | past | comments | ask | show | jobs | submitlogin

A very under-researched subject is the effect of stimulants on the cerebellum dopaminergic neurons. And conversely, the impact of the cerebellum in ADHD.

BTW ADHD drugs are extremely interesting philosophically speaking since they generally work in mammals and involve more or less the same regions and deficits than in humans despite the outcome being an impact on higher order cognitive functions such as the subjective state of eugeroytidue and the allocation of attention ~= the allocation of consciousness. Despite the common yet ungrounded belief of non-human attention/consciousness being significantly different.



> eugeroytidue

If the SERP is to be trusted, this page is the only one on the internet that uses this word. I assume it has something to do with "eugeroic" (wakefulness-promoting drugs).

Anyway I find most discussions about consciousness to be rather boring since everyone has their own wishy-washy definition of it. Stuff that’s philosophically interesting to one person will be trivial to others.


yes eugeroytude is a grammatically valid inflection (https://en.wikipedia.org/wiki/Inflection) of the base form eugeroic. I frequently create unique on the internet inflections, which is very disappointing.

And no it's not an empty philosophical discussion, it litterally means higher cognitive functions have more or less the same locations between a human and a rodent which is a strong signal for us being not that different. If you wanna see an interesting discussion on consciousness with a concrete no-bullshit example, see the end of my comment here: (where btw I use another unique on HN word) https://hn.algolia.com/?dateRange=pastMonth&page=0&prefix=fa...


> I frequently create unique on the internet inflections, which is very disappointing. [sic]

You should probably focus more on getting your point across clearly and succinctly than creating new words which will cause the vast majority of people to either try to derive from context, with mixed success, or just ignore your comment completely.


Hah, it wasn’t just me that tried to search for this word and only came across this page…


semantic accuracy matter more than accessibility, especially in a world where espitemology is not taught. But yeah I agree for this specific instance.


>semantic accuracy matter more than accessibility,

Is that your opinion or the conclusion of a study I’m unaware of?

>…especially in a world where espitemology is not taught.

Which is an argument to use more accessible language.


Congratulations! You are the only person to have ever used the word "eugeroytidue" :)


yes but I made a typo :/ the correct writing would be eugeroytude, still unique though


Being as the word doesn't appear to exist outside your construction of it, it may have been clearer if you had called it "eugeroic-ness" or something. That would have made it clear it was a construction for lack of an accepted adjective form and would have been much easier for me to parse out. On top of the accidental swapped letters, the "i" being exchanged for a "y" made it harder for me to recognize.


You are right.


Evolution reuses parts, a lot. For example, serotonin has some effect on crabs too--it doesn't mean the function is the same as in humans or that psychotherapy for crabs is a good idea.


You miss the point, here the function is the same and rodents on adderall have a better quality of life or at least better attention.


And how do you know a rat has better quality of life? Attention sure, but that isn't necessarily indicative of higher brain function. I believe when you're not paying attention to anything the DMN(default mode network) is active, which doesn't mean very much.


I'm not sure how many people on amphetamine you've seen but it's a group not generally known for the quality of life they enjoy.

Edit to reply because of comment limit: Perhaps I misunderstood, but this example of rats on amphetamine doesn't say anything about any genetic defects.


> I'm not sure how many people on amphetamine you've seen but it's a group not generally known for the quality of life they enjoy.

I’m betting you may know more people who take amphetamine in therapeutic doses than you think - assuming it or other medications that break down into amphetamine (vyvance) are legal to prescribe where you live. Methamphetamine is similar but very different in bioavailability and minimum effective dose (“methylation” is interesting but not relevant to go into here). It is largely believed that the ill effects of meth is primarily due to the garbage they cut it with before being sold on the street.

Amphetamine is tolerated exceptionally well and is very safe at therapeutic doses and has been used as such for 80-some years. If there were major issues identified with it, we would have seen late night TV advertisements from law offices promising to get you a settlement if you or someone you know has used it. The truth is, this is one of the most effective medications we have in modern medicine with 70% of patients reporting major improvement to their lives when on the correct dose. The fact that it’s in schedule II in the US is a travesty given how many hoops one must jump through every month just to get a script filled especially considering it very effectively treats a disorder that makes following through with that stuff difficult.


Do you know wether methamph and methylphenidate as act pharmacologically relevant methyl donors, like SAM-e?


I’m afraid my knowledge is very limited on this and I’m not confident enough to even give an educated guess.


ah yes almagaming people with recreational abuse from people with life changing medication that address genetic deficits. This is because of people like you adderall is not prescribed in many european countries.


I'm definitely not that reason as I'm one of the more loud supporters of it in my country.

But this connection with the rat experiment is not something you want to use as an example of the benefits. The experiment shows that animals would rather absolutely destroy themselves than live without it, and they deteriorate during the experiment a lot too.


> Despite the common yet ungrounded belief of non-human attention/consciousness being significantly different.

I think that's the local phenomenon of the USA. We hear from the American sources sometimes even that animals are supposedly lacking self-awareness.

Whereas anybody who owned a cat or a dog (and not from the USA) is pretty sure that ain't true.


I wish toxoplasmogondi contamined more people already..




Guidelines | FAQ | Lists | API | Security | Legal | Apply to YC | Contact

Search: