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I try to keep up with the AGE breaker development, I thought there were at least one or two labs/companies trying to develop them.

I think IIRC that the crosslink breakers (referring to AGE above for those OOTL) mainly struggle from delivery being difficult? Because many of the AGEs we care about can end up in some bizzare, hard-to-reach places? I think?

I don't think this is directly related but there was one therapy for cellulite that just had an enzyme that dissolved collagen. I just learned that they (sadly, in the long run for the research field in that area) had to shutter that after only two years or so, apparently due to the bruising and discoloration of skin long term (https://investor.endo.com/news-releases/news-release-details...). I guess I can only feel so bad as they were marketing pretty heavily to people who were rich enough to pay for the cosmetic surgery out of pocket, and were as well in a category of middle-aged "luxury" buyers (from the official website -- I don't think the wayback machine will show the pictures [warning, very butt focused], but perhaps for the better, the saved version has the desktop and mobile transcript. Confetti for a medical drug advertisement website. Incredible: https://web.archive.org/web/20210124142605/https://www.qwo.c...)

Lipofuscein I'd love to learn about, I have not heard of that before.




Interesting stuff, glad to see that the research is continuing in this area. I'm thinking about experimenting with topical alagebrium just to see if it does anything. I recall a study in mice that found a very significant effect on skin wrinkles in aged animals.

And it's lipofuscin, I mistyped it. Basically oxidized junk molecules that never seem to get broken down and just accumulate within the cell with age. Interestingly, piracetam seems to have a positive effect on this in rodent brains.




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