It depends on how many objects you installed the ephemerons. We tested with hundreds of thousands of ephemerons and we saw performance problems. We instrumented the code to capture all object allocations of an application. But, if you use ephemerons with not so many objects, let's say a couple of houndreds max, you should not have any issue.
https://github.com/pharo-project/pheps/blob/main/phep-0003.m...
https://thepharo.dev/2021/04/07/a-taste-of-ephemerons/
But I do not know if Guille has some benchmarks.