Yes. Nue is probably not a good pick for people who really like things like React and Tailwind. It's more like going backwards in time when standard HTML, CSS, and vanilla JavaScript was a thing.
How exactly do you use Tailwind without knowing how to use regular CSS first? Pretty much everyone I known uses Tailwind BECAUSE dealing with CSS is a fucking nightmare, even in component-based frameworks.
I know CSS and have to look always into the Tailwind documentation to find the corresponding settings. As long as you use tailwind 0815 settings everything is ok, but not easier as css (if you know css).