I've found most macOS software is actually pretty good at respecting the scrollbar visibility preference, not that we should expect anything less given how often we are told that the Mac is where you go for good UX, and that software developers for it know what they're doing.

(Acrobat recently got this wrong, and I was hearted to discover there's a fairly active thread an the Adobe forums about how much of a fuckup this is. I am not alone! I added a comment or two, of course)