Not exactly what you were asking, but winevdm [0] does use code from Wine to run 16-bit Windows applications on 64-bit Windows installs that don't support it natively (via ntvdm).
While the specific names escape me, there have been a few projects over the years that have replaced DirectDraw or Direct X DLL files with re-implemented counterparts that tend to work much better on modern hardware.
I believe in one such case, the original StarCraft would run with really buggy colors using the official Windows DLL files and a drop-in DLL replacement would fix the issue (these days I think Blizzard has shipped their own fix for this issue).
Another would be DXWND which is amazing :)
It has a ton of options that not only fix various issues with old games but you even have additional features like an ability to run games that never had that support in windowed mode.
I've seen a blog post in the past about running it under WSL so it's entirely possible. That said you could probably just side-load Winlator in Windows 11 as well
Wine is part of this project[1] to run 16-bit windows executables on 64-bit windows. But I think I've seen it referred to generally as 'wine for windows'. It's definitely been a target at times, but I can't find it at the moment.
