Getting a 10x Lethal dose just doesn't seem like a realistic concern to me, and certainly not a dealbreaker.
We know and knew what a normal exposure was: being in close proximity to one or more contagious people for somewhere between a few minutes and many days.
If you have someone sit next to an infected person for an hour, how do you get to this hypothetical 10x super dose?
Edit: I would also add that medical trials also have well established methods of determining effective and dangerous exposure levels, and these are used in almost every Phase 1 trail. You start with extremely low exposure, then increase it until you see dangerous outcomes. This could easily be done with a covid serum to find the infectious but non-lethal level. for example, if you think X amount of covid virus is infectious, you start at 0.0001 X and then increment up, to find the amount that causes normal infection, and not some lethal mega dose.
> Edit: I would also add that medical trials also have well established methods of determining effective and dangerous exposure levels, and these are used in almost every Phase 1 trail.
Yeah, so the scientist I heard this from didn't say it would be impossible to find the right dose, just that we didn't know the dose yet and we'd have to find it before running a challenge trial.
He thought this erased the time savings of a challenge trial versus the normal process.
We know and knew what a normal exposure was: being in close proximity to one or more contagious people for somewhere between a few minutes and many days.
If you have someone sit next to an infected person for an hour, how do you get to this hypothetical 10x super dose?
Edit: I would also add that medical trials also have well established methods of determining effective and dangerous exposure levels, and these are used in almost every Phase 1 trail. You start with extremely low exposure, then increase it until you see dangerous outcomes. This could easily be done with a covid serum to find the infectious but non-lethal level. for example, if you think X amount of covid virus is infectious, you start at 0.0001 X and then increment up, to find the amount that causes normal infection, and not some lethal mega dose.