Ads are unwanted. If you serve ads, you are doing something unwanted to your visitors. So they block the ads, and you get the unwanted effect of not making money. The pain point is not that your ads are being blocked — it’s that you don’t have a way to make money that doesn’t start with doing something unwanted.
It's the way ads are delivered that is unwanted. I would not care about a static inline banner ad at the top of a page. Slightly possible that I'm interested in it if it's relevant in the context of the page, easy to ignore if not.
The ads that pop up when I scroll, or ads between every paragraph (or more) or ads that are animated or use fancy CSS to overlay the main content or slide in from the side and float around -- those are what make me run an adblocker.
