Maybe a receptor resistance build up? Seems to be a common pattern that medicati...

AbstractH24 · 2025-01-15T16:50:58 1736959858

I'm not quite sure I'm smart enough to follow.

Don't sNRIs increase the availability of norepinephrine rather than decrease it? Which is effectively the equivalent of producing more, not less?

seventytwo · 2025-01-15T17:50:18 1736963418

In that case, the body would theoretically adjust to down regulate the production of norepinephrine, since there’s already reuptake has been reduced.

But… I’m not sure it really works that simply in a real brain.