Tangentially, risks like that are why I'm really frustrated-with/exasperated-by certain mRNA-vaccine scaremongers: Ones who act as if older techniques were already fine and sufficient.
It can both be the case that old methods have risks and new methods have greater risks, eg, underestimating mRNA distribution in the body, leading to mRNA replication in heart tissue, and higher than expect dangerous side-effects.
In general, people prefer understood risks to new risks because the system is better adapted to them — both biologically and politically.
Ex: https://www.cdc.gov/vaccines/vpd/polio/hcp/vaccine-derived-p...