Which ironically means the US also loses it's leverage. They're already threatening to functionally (if not actually) withdraw from NATO and economically split off via tariffs. The next step is actual invasion, which while sorta-kinda has been talked about with Greenland, probably won't happen.
I can see Trump putting hostile troops in Greenland. Tiny population despite the size, and I think Trump (at least) does not believe Europe would respond seriously.
I don't even know how Europe would respond to that, and I live in Berlin.
Canada… not so much. For all the talk, he'd be absolutely screwed if he tried. If you think Fentanyl is a problem now, wait until it's supplied for free by drones sent by Canadian civilians paying for it out of pocket because they've never heard of the Geneva Convention or the Chemical Weapons Convention.
(Harder done than said, of course; if it was that easy to mess with populations, western Russia would be high as a kite right now).
Europe will respond with drastic economic sanctions that will act quickly. Tariffs are slow to make a difference, but EU have prepared what they call an economic “bazooka”, that will very quickly hit US economy if force is used against a member state.