> During adulthood, the fat cells themselves just get larger.
While true, it's also important to note that the lifetime of a fat cell is around ten years. Maintaining a decent diet for around ten years (no mean feat!) should be sufficient to leave you bereft of the actual adipose cells.
I also wonder how this intersects with transgender stuff — there's a reason why HRT is referred to as "second puberty", as it resets and changes a lot of underlying biological mechanisms and produces a lot of interesting epigenetic effects (While it does boil down to "replacing the sex hormone", both estrogen and testosterone have major effects on the body's immune system, etc. — actually this is one of the reasons I suspect that there's such a high comorbidity of autoimmune diseases within transgender people pre-HRT — their immune system is all out of wack! Mine calmed down a lot after starting and a year in I no longer get seasonal allergies). There's a huge lack of data in this regard though because transgender bodies are generally not felt to be worth studying outside of "health risks", even though there's a huge amount of information we could glean about how everyone's* body functions from it. Personally, I wonder whether second-puberty "resets" what the body decides is the baseline for fat storage.
* — and for anyone in doubt, we have around 90 years of HRT now that shows it's essentially completely safe (outside of the mid-80s when the estrogen being given was synthetic and non-bio-identical, and outside of the health risks of various things for trans women changing to be roughly equivalent of cis women's health risks).
While true, it's also important to note that the lifetime of a fat cell is around ten years. Maintaining a decent diet for around ten years (no mean feat!) should be sufficient to leave you bereft of the actual adipose cells.
I also wonder how this intersects with transgender stuff — there's a reason why HRT is referred to as "second puberty", as it resets and changes a lot of underlying biological mechanisms and produces a lot of interesting epigenetic effects (While it does boil down to "replacing the sex hormone", both estrogen and testosterone have major effects on the body's immune system, etc. — actually this is one of the reasons I suspect that there's such a high comorbidity of autoimmune diseases within transgender people pre-HRT — their immune system is all out of wack! Mine calmed down a lot after starting and a year in I no longer get seasonal allergies). There's a huge lack of data in this regard though because transgender bodies are generally not felt to be worth studying outside of "health risks", even though there's a huge amount of information we could glean about how everyone's* body functions from it. Personally, I wonder whether second-puberty "resets" what the body decides is the baseline for fat storage.
* — and for anyone in doubt, we have around 90 years of HRT now that shows it's essentially completely safe (outside of the mid-80s when the estrogen being given was synthetic and non-bio-identical, and outside of the health risks of various things for trans women changing to be roughly equivalent of cis women's health risks).