There are very few cultures with 0 tolerance for e.g. nicotine or especially caffeine.
I'm not sure new drugs are even needed. There are plenty of existing drugs, and the vast majority are less harmful than alcohol. They would of course need legal and cultural regulation. There are also some ideas for new recreational substances like David Nutt's "synthetic alcohol".
I'm not sure new drugs are even needed. There are plenty of existing drugs, and the vast majority are less harmful than alcohol. They would of course need legal and cultural regulation. There are also some ideas for new recreational substances like David Nutt's "synthetic alcohol".