It's definitely an interesting outcome and nice to see such a significant improvement in a clinical trial.
And as the article states, there are questions that aren't addressed - does the reduction in obstructive events change the clinical symptoms such as daytime sleepiness? Intuitively you would think it does, but it should be measured in the trial. I also didn't see anything about adverse events during the trial. Seems like taking a stimulant might cause insomnia in some patients.
> In addition, 22% of the treated patients achieved complete control of the disease, defined as fewer than five airway obstructing events per hour.
This surprised me - 5 obstructive events per hour is "complete control of the disease"?
> scientists in Boston a decade ago identified a combination of two existing medications that kept the upper airway open by jointly stimulating the relevant muscles, particularly the genioglossus, a workhorse that forms most of the base of the tongue and is critical to keeping the throat open.
Glad it worked for you. Not everyone with sleep apnea is an overweight alcoholic. Plenty of drugs help with diseases involving muscle tone, why is that so surprising?
And as the article states, there are questions that aren't addressed - does the reduction in obstructive events change the clinical symptoms such as daytime sleepiness? Intuitively you would think it does, but it should be measured in the trial. I also didn't see anything about adverse events during the trial. Seems like taking a stimulant might cause insomnia in some patients.
> In addition, 22% of the treated patients achieved complete control of the disease, defined as fewer than five airway obstructing events per hour.
This surprised me - 5 obstructive events per hour is "complete control of the disease"?
It looks like this is the clinical trial: https://clinicaltrials.gov/study/NCT05813275