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One example off the top of my head: eating lots of protein to build muscle can be hard on the liver.

Exercising a lot is generally healthy, but high impact exercises (running comes to mind) can cause your joints to wear out a lot faster.

This is all also assuming an average, healthy person with no existing medical conditions. Things get trickier if you have exertional asthma, any kind of condition that can cause fatigue, etc.




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