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One side effect of RO is vitamin B12 deficiency. And there is some debate around whether that is true or not, but anecdotally, I had developed a severe B12 deficiency to the point that one day out of the blue, I couldn’t move one of my legs. I freaked out and went to the ER, and it turns out, 1 B12 shot later, I went back to normal within minutes. The doctor hypothesized that I had developed a severe B12 deficiency because of RO water and that I supplement my food with B12 supplements. The regular intake of meat/eggs wasn’t sufficient to compensate for the lack of B12 absorption.



The only papers I could find in Google Scholar about this connection all come from India, and does not seem strongly connected. The study at https://journals.lww.com/jfmpc/fulltext/2025/04000/prevalenc... , for example, says:

> While some studies have hypothesized that the use of RO water could contribute to vitamin B12 deficiency, no significant differences were observed in this study.[20] Symptoms of deficiency were not significantly associated with serum vitamin deficiency status. Only VDD was significantly associated with fatigue as a symptom. This discrepancy raises questions about the current normative values for vitamin B12 and vitamin D3 in the Indian population and suggests the need for further research.

A whole lot of people drink RO water. If it were a simple correlation, I would expect to see cases and papers from all across the world.

I also know there's a long history of false claims along the lines "distilled water sucks the minerals from your body", also called "hungry water". I first heard in the 1980s as a supposed reason for not using distilled water in a radiator. Or even commentary of it in the Carnivorous Plant FAQ at https://www.sarracenia.com/faq/faq3385.html .

Because of that long history, and the lack of a good mechanism for how it should work, I need a much higher level of evidence for a direct, causal connection.


What's the mechanism here? Because it's not like there is B12 supplements in the water.


reverse osmosis removes minerals like cobalt, which are used for b12 production

if you only drink ro water it can creep up on you, but takes some time


How much Co is in your water compared to your food. EPA says just 2 ppb in tap water. This means if you drink about 40 fl.oz. per day you only get 2ug of Co from your water. Per the EPA you get about 2-20x more from your food. Pretty much in no cases is your water a source of nutrients.

refs:

https://www.epa.gov/sites/default/files/2016-09/documents/co...

https://www.cdc.gov/nutrition/php/data-research/fast-facts-w...


This is my understanding too. There are microscopic amounts of trace elements here or there but in reality none of them add up to anything meaningful compared to what you get from food, multivitamins, or other less ideal means.

Rather if they did there'd be probably quite a lot of concern.

Not sure where that old wive's tale came from but even my parents had similar concerns against filtered water ages ago.


I've heard doctors repeat it too, though more as an overall mineral deficiency from already poor diets (which is the bigger issue)


It's not used for b12 production in human metabolism. It is, after all, a vitamin. Is this about cobalt deficiency in dairy and meat animals?


We humans cannot synthesize cobalamins from inorganic cobalt.


If water is giving you any nutrient in a significant manner, change your diet.


Some essential micronutrients such as arsenic are primarily sourced from water. You don’t need much so most natural sources contain enough. There is actually a valid concern that obsessive over-purification of drinking water can lead to deficiencies of some trace minerals.


Wow this has gone off the rails quickly.

To wit: Arsenic is not an essential micronutrient.

"Trace quantities of arsenic have been proposed to be an essential dietary element in rats, hamsters, goats, and chickens. Research has not been conducted to determine whether small amounts of arsenic may play a role in human metabolism." [1]

[1] https://en.wikipedia.org/wiki/Arsenic


There is substantial evidence that arsenic is a required micronutrient in all mammalian biology. This is not even controversial, you can reliably induce deficiency syndromes in a broad spectrum of animal models, and the operative pathways exist in humans. The effect was first observed in animal husbandry in parts of the world with very low background arsenic levels.

It has the same toxicity and micronutrient profile as selenium, another extremely toxic but nonetheless essential micronutrient. Unfortunately, activists with an unrelated agenda have been spreading unscientific misinformation about arsenic to advance that agenda.

Same story as fluoride outrage actually. Being anti-science is fashionable and most people are ignorant about chemistry.

It is one thing that makes me glad I am no longer a practicing chemist.


If what you are saying is true – and I am not being sarcastic - I encourage you to edit and update the Wikipedia page that I referenced.

The authority that I have appealed to (Wikipedia) is a reasonable one and bias should not be implied in the absence of these supposed corrections you have to make.

I’m open-minded …


A tertiary source aims to be non-authoritative. Wikipedia tries pretty hard at it.


Eat a serving of rice, preferably American, without rinsing it.

Enjoy your 10000% recommended daily intake of Arsenic.


Background levels are much higher than current standards with no observable effects in many parts of the world. This is well-studied. There is a threshold but it is higher than people assume.

Plant-based arsenic often has poor bioavailability. Quite a few plants people eat are natural accumulators but it just passes through. Pesticides and geology are the primary bioavailable sources.


I drank only distilled water for 16 years. No supplements all that time, just regular food. No B12 deficiency or any other health issues.


But did you pair it with pure grain alcohol as directed for maximal protection of your precious vital fluids?


The reason I drank it is I like the taste. I am now using an RO filter, and the taste is not as good.


My RO system has a remineralisation cartridge. You def dont want to drink ph neutral water, it feels hard, and doesnt taste sweet.


Similar risks regarding removal of sulfate from public water supply, or via filtration.[1] Who knew! Some of us were relying on actual nutrients from the water all along. Pristine water was, and is, a challenge for this cohort.

[1] https://biomedres.us/fulltexts/BJSTR.MS.ID.006372.php


In the linked article, rybett@aol.com uses the CORREL function in an openoffice spreadsheet to determine a weak correlation between autism diagnoses and sulfur content in tap water in a few regions of New Jersey.

His other publications include a self-published amazon book titled Autism, Enzymes and the Brimstone Demons. [1]

[1] https://www.amazon.com/Autism-Enzymes-Brimstone-Demons-Trill...


So does that mean you are persuaded or that the author doesn't have the right pedigree for you to listen? Because when you set aside the author's idiosyncrasies, there is indeed something remarkable.

Drinking sulfate won't repair broken sulfur metabolism, but it's completely plausible that a subset of people maintained adequate day-to-day function with the benefit of sulfate-laden water, and now fall below the threshold with sulfate mostly removed.


Interesting.

I'm on a well, but with super hard water. So I have a water cooler, which I empty into a Brita pitcher, but just for drinking.

Just for the flavour.

I cook with my hard water though. Lots of stews and soups too, make bread, etc. So I suspect I get sufficiently mineralised as a result.

For context, I was boiling a large pot of water and got distracted by a call. Most of the water boiled away, well over a gallon. I was left with a solid white disk of calcium at the bottom. Also, when I broke it to get it out, it was super sharp, almost cut myself.




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