Always hard to tell what and where specifically the impacts of any research will be. Looking at how they discuss the creating of this lnp formulation in the paper:
> We therefore modified the lipid composition of the LNP to enhance potency. First, the ionisable lipid DLin-MC3-DMA (MC3) was replaced with SM-102, an ionisable lipid previously shown to lead to greater cytosolic mRNA delivery through enhanced endosomal escape [30]. Second, the SM-102-LNPs were further modified using ß-sitosterol, a naturally-occurring cholesterol analogue associated with enhanced mRNA delivery [31], to create a formulation referred to as LNP X (Fig. 1b).
Neither of those papers they cited were focused on HIV/T cells specifically. Maybe this will have no applications, or applications in HIV only, or be generally useful for hard to transfect cells, or be bad for HIV for some unforseen reason but useful elsewhere, or be a dead end, you never know. But yeah maybe if folks run into similar challenges for approaches to dealing with those viruses, maybe there's something from this work that could help them, who knows?
> We therefore modified the lipid composition of the LNP to enhance potency. First, the ionisable lipid DLin-MC3-DMA (MC3) was replaced with SM-102, an ionisable lipid previously shown to lead to greater cytosolic mRNA delivery through enhanced endosomal escape [30]. Second, the SM-102-LNPs were further modified using ß-sitosterol, a naturally-occurring cholesterol analogue associated with enhanced mRNA delivery [31], to create a formulation referred to as LNP X (Fig. 1b).
[30]: https://pubmed.ncbi.nlm.nih.gov/29653760/
[31]: https://pubmed.ncbi.nlm.nih.gov/32080183/
Neither of those papers they cited were focused on HIV/T cells specifically. Maybe this will have no applications, or applications in HIV only, or be generally useful for hard to transfect cells, or be bad for HIV for some unforseen reason but useful elsewhere, or be a dead end, you never know. But yeah maybe if folks run into similar challenges for approaches to dealing with those viruses, maybe there's something from this work that could help them, who knows?