I live in Boston where I make double(-ish) the household median income ($80k to $100k). For individual median incomes, I make $140k more. I'm able to save over half my monthly income and it's still not enough. I absolutely can't imagine living in this city on anything less and I don't exactly live a life of exuberance here.
Exceptions are HCOL tech hubs, but comp in those places is much higher.