Generally it works well, but what's particularly annoying is that it hides cookie walls, resulting in non-functional websites until I disable content blockers, close the dialog and re-enable them. Not sure if uBlock does any better, though.
Ghostery does the same, but has more fine-grained per-website controls. You can for example turn off just the consent-popup-blocker function for a website while keeping the anti-tracking ad-blocking functions.
Use Safari’s own built-in “Hide Distracting Items”. It’s also pretty good at hiding the few remaining “disable your ad blocker to continue” popups Wipr doesn’t yet catch.