GTO goes out the window when a drunk guy sits down with a few friends. Either you're gonna grab the pot a few times or bust because the dude went all in with dueces against your KA. he wins a flush on the river.
Drunk guys are the easisest to play against. You don't need GTO, you can just play exploitatively and adjust your range against his, so that you still have big range advantige preflop. And you can lower variance and decide to not go all-in with AK preflop, but this also depends on how deep the effective stack is in a given situation.
