Not only are Ctl+C and Ctl+V not next to each other, but they move next to other shortcuts that are annoying to mis-hit, like the one to close a browser tab...

Remapping the shortcuts is possible but too much effort; I just live with it.

Fortunately, modern video games seem to understand different layouts and automatically change their input to match the actual finger placement rather than what they QWERTY letters would be.