I'm fairly certain clay pigeon shooting type ammunition and aiming skills stand reasonable chances of hitting even small drones and doing sufficient damage to knock then out of the sky, but only at maybe 50m or so range. A typical attack drone like the types used in Ukraine right now are probably capable doing well over 30m/s on final approach, so it'd be a tough interception still, only about a one second window to get your shot off before it's likely to deliver it's payload ballistically even if you have scored a direct hit.

I suspect the same sort of skills displayed in Ukraine building home made Ardupilot based drones with optical final stage guidance could also be turned to building multi barrel "Phalanx-style" shotgun setups on manual plus computer-optical assisted aiming, in a form factor compact enough to be installed in the back of a Hilux. And that'd be very much the sort of mostly Commercial Off The Shelf approach that seems to do so well tipping the asymmetric warfare in Ukraine's favour in this war.