I've been using them for 4 years across enterprise level HDDs, personal HDDs, portable HDDs, never seen any issues or differences in experience other than speed.
From every success story like yours, how many people have tried it but given up and returned to a commercial solution because of a bug in OMV and absence of support except for a community forum filled with rabid (and usually clueless) fanboys?
So can Synology. "I'm sorry, sir, but your XYZ drive doesn't appear on our list of recommended/supported drives. I'll need to refer you to XYZ Corp for this issue. Is there anything else I can help you with today?"
That's all they ever needed to say. Instead, they said, "Fuck you, pay me."