I've used Tiger/Saint/Satan/COPS in the distant past. But I think they're somewhat obsoleted by modern packaging and security like apparmor and selinux, not to mention docker and similar isolators.
most people like their distro to vet these things. uv et all had a reason when Python2 and 3 were a mess. i think that time is way behind us. pip is mostly to install libraries, and even that is mostly already done by the distros.
uv installing deps is hardly more risky.