I haven’t taken it myself, but I’ve heard of methylene blue being helpful, especially post TBIs or head injuries.
Wrt ibuprofen, I find it can (at times) massively clear out my brain fog. I suspect it’s primarily due to its anti inflammatory effects. The worse my baseline is, the more noticeable its benefits (upto a point, and apparently dose dependent). I often feel inflammation due to less sleep and due to another chronic heath condition, ibuprofen is like wiping a dirty glass or window clean.
I should probably add that I likely have more inflammation than the average person by a significant amount unfortunately, so your mileage may vary, but when I mentioned it to my GP he wasn’t surprised at all at its effects.
Yes, serotonin syndrome is definitely a serious risk. From what I understand, it's typically caused by interactions between SSRIs or MAOIs and substances like methylene blue, rather than methylene blue broadly interacting with many compounds. But I agree - caution is essential when dealing with anything that affects brain chemistry.
Methylene blue is said to allegedly have helped some people with brainfog - especially after covid. But the research is really scarce. Ibuprofen and creatine may also have some positive nootropic effects with recently mounting evidence, but at least they were already very well studied before because of their actual uses. So if anybody wants to try this stuff, I'd stick with those.
