I haven’t taken it myself, but I’ve heard of methylene blue being helpful, especially post TBIs or head injuries.
Wrt ibuprofen, I find it can (at times) massively clear out my brain fog. I suspect it’s primarily due to its anti inflammatory effects. The worse my baseline is, the more noticeable its benefits (upto a point, and apparently dose dependent). I often feel inflammation due to less sleep and due to another chronic heath condition, ibuprofen is like wiping a dirty glass or window clean.
I should probably add that I likely have more inflammation than the average person by a significant amount unfortunately, so your mileage may vary, but when I mentioned it to my GP he wasn’t surprised at all at its effects.
Yes, serotonin syndrome is definitely a serious risk. From what I understand, it's typically caused by interactions between SSRIs or MAOIs and substances like methylene blue, rather than methylene blue broadly interacting with many compounds. But I agree - caution is essential when dealing with anything that affects brain chemistry.
Wrt ibuprofen, I find it can (at times) massively clear out my brain fog. I suspect it’s primarily due to its anti inflammatory effects. The worse my baseline is, the more noticeable its benefits (upto a point, and apparently dose dependent). I often feel inflammation due to less sleep and due to another chronic heath condition, ibuprofen is like wiping a dirty glass or window clean.
I should probably add that I likely have more inflammation than the average person by a significant amount unfortunately, so your mileage may vary, but when I mentioned it to my GP he wasn’t surprised at all at its effects.