Yeah, most GLP-1 benefits (or even adverse effects, like muscle loss) seem to be caused by the weight loss. We already knew obesity massively increases risk from a host of diseases, but GLP-1s are still treated with scepticism of the "oh but what about the side-effects we don't know about?!" variety?
> The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss and had only a small association with waist circumference, suggesting some mechanisms for benefit beyond adiposity reduction.
They won't, GLP-1 has almost no direct effect on skinny people. Many women with BMI around 22-23 are trying them to lose weight to match beauty standards and usually end up disappointed, not able to drop more than 1-2 kilos.
