There’s growing evidence of cardioprotective effects independent of weight loss.
Eg https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
> The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss and had only a small association with waist circumference, suggesting some mechanisms for benefit beyond adiposity reduction.
https://www.kidneyfund.org/treatments/medicines-kidney-disea...
There’s growing evidence of cardioprotective effects independent of weight loss.
Eg https://www.thelancet.com/journals/lancet/article/PIIS0140-6...
> The cardioprotective effects of semaglutide were independent of baseline adiposity and weight loss and had only a small association with waist circumference, suggesting some mechanisms for benefit beyond adiposity reduction.